Esau, the firstborn of Isaac, marries Hittite women.  Genesis 26 tells us that the women were a source of grief to Isaac and Rebekah.  These women worshiped false gods and no doubt lured Esau into pagan practices as well.  God repeatedly warns His people to stay away from alliances with pagans.

Jacob received the birthright earlier when Esau bargained for a bowl of soup. The birthright was the scepter promise which gave Jacob the right for future generations to be kings. Jacob deceitfully received the blessing, which gave him and his future descendants riches and power.  The birthright was a legitimate purchase from Esau. The blessing was stolen.

When Isaac wonders at the speed at which the game meat is served, Jacob justifies the deceit by giving credit to God.  Hmmm...not a good thing!

The blessings given to Jacob are extremely significant prophetically, both literally (physically) and spiritually (figuratively).   Jacob later will be known as Israel, father of the 12 tribes of Israel.
Gen 27:28-29
May God give you of heaven's dew and of earth's richness - an abundance of grain and new wine.  May nations serve you and peoples bow down to you. Be lord over your brothers, and may the sons of your mother bow down to you.  May those who curse you be cursed and those who bless you be blessed.
May nations serve you and peoples bow down to you. While nations will not serve the man, Jacob, nations will serve Israel.  During portions of the reign of King David, and in the days of King Solomon nations did serve and honor the nation of Israel.  In our day, some nations honor Israel, but most do not.  However, during the millennial kingdom, ALL nations will serve and honor Israel.  
Be lord over your brothers, and may the sons of your mother bow down to you.  Jacob had only one brother so the plural use of the word brothers must mean brothers in a figurative sense.  The nation of Israel will one day be lord over all the other nations.  Interestingly, Esau's descendants will settle in Edom and be known as Edomites, in the land now known as Jordan, home of Arabs and Palestinians.

Esau discovers the deception of Jacob and pleads with his father to bless him as well.  Since Isaac had already given the great blessings to Jacob, there appears to be practically nothing left.  While in today's business and family inheritance dealings, if inheritance was received through fraud, it can easily be retracted. Not so in the culture and customs of those days. Once the words were spoken by a leader or the patriarch of the family, the blessing could not be rescinded.  Because of this deception, Esau determines to kill his brother Jacob, but not until Isaac is dead.

Rebekah fears for Jacob's life and sends him away to Haren. This was not a short journey. It was between 600 and 700 miles away.  When Jacob left, Esau essentially took over all that Isaac had.  But as far as Esau knew, Jacob would return shortly with a wife and claim the inheritance and the blessings.

After Jacob left, Esau marries the daughter of Ishmael, Isaac's half-brother. Esau did this to spite his parents even more.

Jacob stops at a place that he will later name Bethel (house of God).  This land now where Bethel is located is in the present day "West Bank" in occupied territory where Christians and Messianic Jews are unwelcome.

What is the significance of angels ascending and descending from heaven in the dream that Jacob had? Does it have something to do with angels interacting with humans now? Jesus told the disciple Nathanael that he too would see something similar.

John 1:51
He then added, "I tell you the truth, you shall see heaven open, and the angels of God ascending and descending on the Son of Man."

Jacob names the place Bethel, which means house of God. It is here that God confirms the promise that He made earlier to Abraham and He offers this same promise to Jacob. Bethel became an important center for worship but later became a center for idol worship, which the prophet Hosea condemned. Isn't that just like Satan? He takes a place for worship of God and turns it into something evil. This makes us want to guard closely our place of worship and be careful to keep evil from slipping in.